DISEASES

Disease-gene associations mined from literature

Literature on CX3CL1

CX3CL1 [ENSP00000006053]

Processed fractalkine; Acts as a ligand for both CX3CR1 and integrins. Binds to CX3CR1 . Binds to integrins ITGAV:ITGB3 and ITGA4:ITGB1. Can activate integrins in both a CX3CR1-dependent and CX3CR1-independent manner. In the presence of CX3CR1, activates integrins by binding to the classical ligand-binding site (site 1) in integrins. In the absence of CX3CR1, binds to a second site (site 2) in integrins which is distinct from site 1 and enhances the binding of other integrin ligands to site 1 (PubMed:23125415, PubMed:24789099). The soluble form is chemotactic for T-cells and monocytes and not for neutrophils. The membrane-bound form promotes adhesion of those leukocytes to endothelial cells. May play a role in regulating leukocyte adhesion and migration processes at the endothelium . ECO:0000269|PubMed:24789099, ECO:0000269|PubMed:9024663,

Synonyms:  CX3CL1,  CX3CL1p,  hCX3CL1,  A0N0N7,  H3BSR6 ...

Linkouts:  STRING  Pharos  UniProt  OMIM