DISEASES

Disease-gene associations mined from literature

Literature on GIGYF2

GIGYF2 [ENSP00000387170]

GRB10-interacting GYF protein 2; Key component of the 4EHP-GYF2 complex, a multiprotein complex that acts as a repressor of translation initiation . In 4EHP-GYF2 the complex, acts as a factor that bridges EIF4E2 to ZFP36/TTP, linking translation repression with mRNA decay (By similarity). May act cooperatively with GRB10 to regulate tyrosine kinase receptor signaling, including IGF1 and insulin receptors ; Belongs to the GIGYF family.

Synonyms:  GIGYF2,  GIGYF2p,  hGIGYF2,  A0A1U8QZH8,  B8ZZD2 ...

Linkouts:  STRING  Pharos  UniProt  OMIM