DISEASES

Disease-gene associations mined from literature

Literature on PREX1

PREX1 [ENSP00000361009]

Phosphatidylinositol 3,4,5-trisphosphate-dependent Rac exchanger 1 protein; Functions as a RAC guanine nucleotide exchange factor (GEF), which activates the Rac proteins by exchanging bound GDP for free GTP. Its activity is synergistically activated by phosphatidylinositol 3,4,5-trisphosphate and the beta gamma subunits of heterotrimeric G protein. May function downstream of heterotrimeric G proteins in neutrophils.

Synonyms:  PREX1,  PREX1p,  hPREX1,  A0A087WY11,  H0YDZ4 ...

Linkouts:  STRING  Pharos  UniProt  OMIM