DISEASES

Disease-gene associations mined from literature

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Literature on MAP3K21

MAP3K21 [ENSP00000355583]

Mitogen-activated protein kinase kinase kinase 21; Negative regulator of TLR4 signaling. Does not activate JNK1/MAPK8 pathway, p38/MAPK14, nor ERK2/MAPK1 pathways.

Synonyms:  MAP3K21,  MAP3K21p,  hMAP3K21,  Q5TCX8,  Q5TCX8p ...

Linkouts:  STRING  Pharos  UniProt

The disease-gene associations are derived from automatic text mining of the biomedical literature, manually curated database annotations, cancer mutation data, and genome-wide association studies. The confidence of each association is signified by stars, where ★★★★★ is the highest confidence and ★☆☆☆☆ is the lowest.

Developed by Sune Frankild, Alexander Junge, Albert Pallejà, Dhouha Grissa, Kalliopi Tsafou, and Lars Juhl Jensen from the Novo Nordisk Foundation Center for Protein Research.