DISEASES

Disease-gene associations mined from literature

Literature on TRIO

TRIO [ENSP00000339299]

Triple functional domain protein; Guanine nucleotide exchange factor (GEF) for RHOA and RAC1 GTPases . Involved in coordinating actin remodeling, which is necessary for cell migration and growth . In developing hippocampal neurons, limits dendrite formation, without affecting the establishment of axon polarity. Once dendrites are formed, involved in the control of synaptic function by regulating the endocytosis of AMPA- selective glutamate receptors (AMPARs) at CA1 excitatory synapses (By similarity). May act as a regulator of adipogenesis (By similarity). ECO:0000269|PubMed:22155786, ECO:0000269|PubMed:27418539,

Synonyms:  TRIO,  A0A087X139,  A0A1W2PRD7,  E7EPJ7,  E7EWP2 ...

Linkouts:  STRING  Pharos  UniProt  OMIM