DISEASES

Disease-gene associations mined from literature

Literature on TRAK1

TRAK1 [ENSP00000328998]

Trafficking kinesin-binding protein 1; Involved in the regulation of endosome-to-lysosome trafficking, including endocytic trafficking of EGF-EGFR complexes and GABA-A receptors . Involved in mitochondrial motility. When O-glycosylated, abolishes mitochondrial motility. Crucial for recruiting OGT to the mitochondrial surface of neuronal processes . TRAK1 and RHOT form an essential protein complex that links KIF5 to mitochondria for light chain-independent, anterograde transport of mitochondria (By similarity). ; Belongs to the milton family.

Synonyms:  TRAK1,  TRAK1p,  hTRAK1,  A0A024R2M0,  A0A087X0N0 ...

Linkouts:  STRING  Pharos  UniProt  OMIM