DISEASES

Disease-gene associations mined from literature

Literature on DNMBP

DNMBP [ENSP00000315659]

Dynamin-binding protein; Plays a critical role as a guanine nucleotide exchange factor (GEF) for CDC42 in several intracellular processes associated with the actin and microtubule cytoskeleton. Regulates the structure of apical junctions through F-actin organization in epithelial cells . Participates in the normal lumenogenesis of epithelial cell cysts by regulating spindle orientation . Plays a role in ciliogenesis (By similarity). May play a role in membrane trafficking between the cell surface and the Golgi (By similarity). ECO:0000250|UniProtKB:Q6TXD4, ECO:0000269|PubMed:17015620,

Synonyms:  DNMBP,  A0A1B0GTX1,  A0A1C7CYY6,  Q6XZF7,  Q6XZF7p ...

Linkouts:  STRING  Pharos  UniProt  OMIM