DISEASES

Disease-gene associations mined from literature

Literature on PPP1R16B

PPP1R16B [ENSP00000299824]

Protein phosphatase 1 regulatory inhibitor subunit 16B; Regulator of protein phosphatase 1 (PP1) that acts as a positive regulator of pulmonary endothelial cell (EC) barrier function . Involved in the regulation of the PI3K/AKT signaling pathway, angiogenesis and endothelial cell proliferation . Regulates angiogenesis and endothelial cell proliferation through the control of ECE1 dephosphorylation, trafficking and activity (By similarity). Protects the endothelial barrier from lipopolysaccharide (LPS)-induced vascular leakage (By similarity). Involved in the regulation of endothelial cell filopodia extension (By similarity). May be a downstream target for TGF-beta1 signaling cascade in endothelial cells (PubMed:16263087, PubMed:18586956). Involved in PKA-mediated moesin dephosphorylation which is important in EC barrier protection against thrombin stimulation . Promotes the interaction of PPP1CA with RPSA/LAMR1 and in turn facilitates the dephosphorylation of RPSA/LAMR1 . Involved in the dephosphorylation of EEF1A1 . ECO:0000250|UniProtKB:Q95N27, ECO:0000269|PubMed:16263087, ECO:0000269|PubMed:18586956, ECO:0000269|PubMed:25007873,

Synonyms:  PPP1R16B,  Q96T49,  Q96T49p,  hQ96T49,  26051 ...

Linkouts:  STRING  Pharos  UniProt  OMIM