DISEASES

Disease-gene associations mined from literature

Literature on NVL

NVL [ENSP00000281701]

Nuclear valosin-containing protein-like; Participates in the assembly of the telomerase holoenzyme and effecting of telomerase activity via its interaction with TERT . Involved in both early and late stages of the pre- rRNA processing pathways . Spatiotemporally regulates 60S ribosomal subunit biogenesis in the nucleolus (PubMed:15469983, PubMed:16782053, PubMed:29107693, PubMed:26456651). Catalyzes the release of specific assembly factors, such as WDR74, from pre-60S ribosomal particles through the ATPase activity (PubMed:29107693, PubMed:26456651, PubMed:28416111). ECO:0000269|PubMed:16782053, ECO:0000269|PubMed:22226966, ECO:0000269|PubMed:26166824, ECO:0000269|PubMed:26456651,

Synonyms:  NVL,  A0A087WV72,  C9J6P7,  C9JP83,  E7EWK7 ...

Linkouts:  STRING  Pharos  UniProt  OMIM