DISEASES

Disease-gene associations mined from literature

Literature on LRRFIP1

LRRFIP1 [ENSP00000375857]

Leucine-rich repeat flightless-interacting protein 1; Transcriptional repressor which preferentially binds to the GC-rich consensus sequence (5'-AGCCCCCGGCG-3') and may regulate expression of TNF, EGFR and PDGFA. May control smooth muscle cells proliferation following artery injury through PDGFA repression. May also bind double-stranded RNA. Positively regulates Toll-like receptor (TLR) signaling in response to agonist probably by competing with the negative FLII regulator for MYD88-binding. ECO:0000269|PubMed:16199883, ECO:0000269|PubMed:19265123,

Synonyms:  LRRFIP1,  LRRFIP1p,  hLRRFIP1,  A0A0F7NGI8,  C9JTC6 ...

Linkouts:  STRING  Pharos  UniProt  OMIM