DISEASES

Disease-gene associations mined from literature

Literature on CBX6

CBX6 [ENSP00000384490]

Chromobox protein homolog 6; Component of a Polycomb group (PcG) multiprotein PRC1-like complex, a complex class required to maintain the transcriptionally repressive state of many genes, including Hox genes, throughout development . PcG PRC1 complex acts via chromatin remodeling and modification of histones; it mediates monoubiquitination of histone H2A 'Lys-119', rendering chromatin heritably changed in its expressibility. Possibly contributes to the target selectivity of the PRC1 complex by binding specific regions of chromatin . Recruitment to chromatin might occur in an H3K27me3- independent fashion (By similarity). May have a PRC1-independent function in embryonic stem cells (By similarity).

Synonyms:  CBX6,  CBX6p,  hCBX6,  B0QXZ6,  O95503 ...

Linkouts:  STRING  Pharos  UniProt