DISEASES

Disease-gene associations mined from literature

Literature on TRIM27

TRIM27 [ENSP00000366404]

Zinc finger protein RFP; E3 ubiquitin-protein ligase that mediates ubiquitination of PIK3C2B and inhibits its activity; mediates the formation of 'Lys-48'- linked polyubiquitin chains; the function inhibits CD4 T-cell activation. Acts as a regulator of retrograde transport: together with MAGEL2, mediates the formation of 'Lys-63'-linked polyubiquitin chains at 'Lys-220' of WASHC1, leading to promote endosomal F-actin assembly . Has a transcriptional repressor activity by cooperating with EPC1. Induces apoptosis by activating Jun N-terminal kinase and p38 kinase and also increases caspase-3-like activity independently of mitochondrial events. May function in male germ cell development. Has DNA-binding activity and preferentially bound to double-stranded DNA. ECO:0000269|PubMed:12807881, ECO:0000269|PubMed:22128329,

Synonyms:  TRIM27,  TRIM27p,  hTRIM27,  A0A1U9X8R9,  H0Y551 ...

Linkouts:  STRING  Pharos  UniProt  OMIM