DISEASES

Disease-gene associations mined from literature

Literature on ZDHHC6

ZDHHC6 [ENSP00000358413]

Palmitoyltransferase ZDHHC6; Endoplasmic reticulum palmitoyl acyltransferase that mediates palmitoylation of proteins such as AMFR, CALX, ITPR1 and TFRC . Palmitoylates calnexin (CALX), which is required for its association with the ribosome-translocon complex and efficient folding of glycosylated proteins . Mediates palmitoylation of AMFR, promoting AMFR distribution to the peripheral endoplasmic reticulum . Together with SELENOK, palmitoylates ITPR1 in immune cells, leading to regulate ITPR1 stability and function . ECO:0000269|PubMed:22728137, ECO:0000269|PubMed:25368151,; Belongs to the DHHC palmitoyltransferase family.

Synonyms:  ZDHHC6,  ZDHHC6p,  hZDHHC6,  A0A0D9SEX5,  Q9H6R6 ...

Linkouts:  STRING  Pharos  UniProt