DISEASES

Disease-gene associations mined from literature

Literature on RGS10

RGS10 [ENSP00000358099]

Regulator of G-protein signaling 10; Regulates G protein-coupled receptor signaling cascades, including signaling downstream of the muscarinic acetylcholine receptor CHRM2. Inhibits signal transduction by increasing the GTPase activity of G protein alpha subunits, thereby driving them into their inactive GDP-bound form (PubMed:8774883, PubMed:10608901, PubMed:9353196, PubMed:11443111, PubMed:18434541). Modulates the activity of potassium channels that are activated in response to CHRM2 signaling . Activity on GNAZ is inhibited by palmitoylation of the G-protein . ECO:0000269|PubMed:11443111, ECO:0000269|PubMed:18434541,

Synonyms:  RGS10,  RGS10p,  hRGS10,  O43665,  O43665p ...

Linkouts:  STRING  Pharos  UniProt  OMIM