DISEASES

Disease-gene associations mined from literature

Literature on SASH1

SASH1 [ENSP00000356437]

SAM and SH3 domain-containing protein 1; Is a positive regulator of NF-kappa-B signaling downstream of TLR4 activation. It acts as a scaffold molecule to assemble a molecular complex that includes TRAF6, MAP3K7, CHUK and IKBKB, thereby facilitating NF-kappa-B signaling activation . Regulates TRAF6 and MAP3K7 ubiquitination . Involved in the regulation of cell mobility (PubMed:23333244, PubMed:23776175, PubMed:25315659). Regulates lipolysaccharide (LPS)-induced endothelial cell migration . Is involved in the regulation of skin pigmentation through the control of melanocyte migration in the epidermis .

Synonyms:  SASH1,  SASH1p,  hSASH1,  A0A087WW74,  A0A1B0GVF9 ...

Linkouts:  STRING  Pharos  UniProt  OMIM