DISEASES

Disease-gene associations mined from literature

Literature on PCGF3

PCGF3 [ENSP00000354724]

Polycomb group RING finger protein 3; Component of a Polycomb group (PcG) multiprotein PRC1-like complex, a complex class required to maintain the transcriptionally repressive state of many genes, including Hox genes, throughout development. PcG PRC1 complex acts via chromatin remodeling and modification of histones; it mediates monoubiquitination of histone H2A 'Lys-119', rendering chromatin heritably changed in its expressibility. Within the PRC1-like complex, regulates RNF2 ubiquitin ligase activity . Plays a redundant role with PCGF5 as part of a PRC1- like complex that mediates monoubiquitination of histone H2A 'Lys-119' on the X chromosome and is required for normal silencing of one copy of the X chromosome in XX females (By similarity).

Synonyms:  PCGF3,  PCGF3p,  hPCGF3,  A0A087WVH5,  B5MEC4 ...

Linkouts:  STRING  Pharos  UniProt