DISEASES

Disease-gene associations mined from literature

Literature on MCRS1

MCRS1 [ENSP00000349640]

Microspherule protein 1; Modulates the transcription repressor activity of DAXX by recruiting it to the nucleolus . As part of the NSL complex it may be involved in acetylation of nucleosomal histone H4 on several lysine residues . Putative regulatory component of the chromatin remodeling INO80 complex which is involved in transcriptional regulation, DNA replication and probably DNA repair. May also be an inhibitor of TERT telomerase activity . Binds to G-quadruplex structures in mRNA . Binds to RNA homopolymer poly(G) and poly(U) .

Synonyms:  MCRS1,  MCRS1p,  hMCRS1,  A0A024R134,  F8VP44 ...

Linkouts:  STRING  Pharos  UniProt  OMIM