DISEASES

Disease-gene associations mined from literature

Literature on IFI6

IFI6 [ENSP00000342513]

Interferon alpha-inducible protein 6; Plays a role in apoptosis, negatively regulating the intrinsinc apoptotic signaling pathway and TNFSF10-induced apoptosis . However, it has also been shown to have a pro-apoptotic activity . Has an antiviral activity towards hepatitis C virus/HCV by inhibiting the EGFR signaling pathway, which activation is required for entry of the virus into cells . ECO:0000269|PubMed:17823654, ECO:0000269|PubMed:25757571,; Belongs to the IFI6/IFI27 family.

Synonyms:  IFI6,  IFI6p,  hIFI6,  A0A348GSI1,  P09912 ...

Linkouts:  STRING  Pharos  UniProt  OMIM