DISEASES

Disease-gene associations mined from literature

Literature on NELFB

NELFB [ENSP00000339495]

Negative elongation factor B; Essential component of the NELF complex, a complex that negatively regulates the elongation of transcription by RNA polymerase II . The NELF complex, which acts via an association with the DSIF complex and causes transcriptional pausing, is counteracted by the P-TEFb kinase complex . May be able to induce chromatin unfolding . Essential for early embryogenesis; plays an important role in maintaining the undifferentiated state of embryonic stem cells (ESCs) by preventing unscheduled expression of developmental genes (By similarity). Plays a key role in establishing the responsiveness of stem cells to developmental cues; facilitates plasticity and cell fate commitment in ESCs by establishing the appropriate expression level of signaling molecules (By similarity). Supports the transcription of genes involved in energy metabolism in cardiomyocytes; facilitates the association of transcription initiation factors with the promoters of the metabolism- related genes (By similarity). ECO:0000269|PubMed:10199401, ECO:0000269|PubMed:11739404,; Belongs to the NELF-B family.

Synonyms:  NELFB,  Q8WX92,  Q8WX92p,  hQ8WX92,  25920 ...

Linkouts:  STRING  Pharos  UniProt