DISEASES

Disease-gene associations mined from literature

Literature on ZFP91

ZFP91 [ENSP00000339030]

E3 ubiquitin-protein ligase ZFP91; Atypical E3 ubiquitin-protein ligase that mediates 'Lys-63'- linked ubiquitination of MAP3K14/NIK, leading to stabilize and activate MAP3K14/NIK. It thereby acts as an activator of the non-canonical NF- kappa-B2/NFKB2 pathway. May also play an important role in cell proliferation and/or anti-apoptosis; Belongs to the krueppel C2H2-type zinc-finger protein family.

Synonyms:  ZFP91,  ZFP91p,  hZFP91,  A0A024R4Z1,  Q96JP5 ...

Linkouts:  STRING  Pharos  UniProt