DISEASES

Disease-gene associations mined from literature

Literature on PCGF5

PCGF5 [ENSP00000337500]

Polycomb group RING finger protein 5; Component of a Polycomb group (PcG) multiprotein PRC1-like complex, a complex class required to maintain the transcriptionally repressive state of many genes, including Hox genes, throughout development. PcG PRC1 complex acts via chromatin remodeling and modification of histones; it mediates monoubiquitination of histone H2A 'Lys-119', rendering chromatin heritably changed in its expressibility . Within the PRC1-like complex, regulates RNF2 ubiquitin ligase activity . Plays a redundant role with PCGF3 as part of a PRC1-like complex that mediates monoubiquitination of histone H2A 'Lys-119' on the X chromosome and is required for normal silencing of one copy of the X chromosome in XX females (By similarity).

Synonyms:  PCGF5,  PCGF5p,  hPCGF5,  Q86SE9,  Q86SE9p ...

Linkouts:  STRING  Pharos  UniProt