DISEASES

Disease-gene associations mined from literature

Literature on TMED9

TMED9 [ENSP00000330945]

Transmembrane emp24 domain-containing protein 9; Appears to be involved in vesicular protein trafficking, mainly in the early secretory pathway. In COPI vesicle-mediated retrograde transport involved in the coatomer recruitment to membranes of the early secretory pathway. Increases coatomer-dependent activity of ARFGAP2. Thought to play a crucial role in the specific retention of p24 complexes in cis-Golgi membranes; specifically contributes to the coupled localization of TMED2 and TMED10 in the cis-Golgi network. May be involved in organization of intracellular membranes, such as of the ER-Golgi intermediate compartment and the Golgi apparatus. Involved in ER localization of PTPN2 isoform PTPB. ECO:0000269|PubMed:14600267, ECO:0000269|PubMed:16595549,

Synonyms:  TMED9,  TMED9p,  hTMED9,  A0A024R7M0,  Q9BVK6 ...

Linkouts:  STRING  Pharos  UniProt