DISEASES

Disease-gene associations mined from literature

Literature on DRG1

DRG1 [ENSP00000329715]

Developmentally-regulated GTP-binding protein 1; Catalyzes the conversion of GTP to GDP through hydrolysis of the gamma-phosphate bond in GTP . Appears to have an intrinsic GTPase activity that is stimulated by ZC3H15/DFRP1 binding likely by increasing the affinity for the potassium ions . When hydroxylated at C-3 of 'Lys-22' by JMJD7, may bind to RNA and play a role in translation . Binds to microtubules and promotes microtubule polymerization and stability that are required for mitotic spindle assembly during prophase to anaphase transition. GTPase activity is not necessary for these microtubule-related functions . ECO:0000269|PubMed:23711155, ECO:0000269|PubMed:28855639,; Belongs to the TRAFAC class OBG-HflX-like GTPase superfamily. OBG GTPase family.

Synonyms:  DRG1,  DRG1p,  hDRG1,  F8WBU4,  F8WEE0 ...

Linkouts:  STRING  Pharos  UniProt  OMIM