Literature on DRG1
DRG1 [ENSP00000329715]
Developmentally-regulated GTP-binding protein 1; Catalyzes the conversion of GTP to GDP through hydrolysis of the gamma-phosphate bond in GTP . Appears to have an intrinsic GTPase activity that is stimulated by ZC3H15/DFRP1 binding likely by increasing the affinity for the potassium ions . When hydroxylated at C-3 of 'Lys-22' by JMJD7, may bind to RNA and play a role in translation . Binds to microtubules and promotes microtubule polymerization and stability that are required for mitotic spindle assembly during prophase to anaphase transition. GTPase activity is not necessary for these microtubule-related functions . ECO:0000269|PubMed:23711155, ECO:0000269|PubMed:28855639,; Belongs to the TRAFAC class OBG-HflX-like GTPase superfamily. OBG GTPase family.
Synonyms: DRG1, DRG1p, hDRG1, F8WBU4, F8WEE0 ...