Literature on OSBPL3
OSBPL3 [ENSP00000315410]
Oxysterol-binding protein-related protein 3; Phosphoinositide-binding protein which associates with both cell and endoplasmic reticulum (ER) membranes . Can bind to the ER membrane protein VAPA and recruit VAPA to plasma membrane sites, thus linking these intracellular compartments . The ORP3-VAPA complex stimulates RRAS signaling which in turn attenuates integrin beta-1 (ITGB1) activation at the cell surface . With VAPA, may regulate ER morphology . Has a role in regulation of the actin cytoskeleton, cell polarity and cell adhesion . Binds to phosphoinositides with preference for PI(3,4)P2 and PI(3,4,5)P3 . Also binds 25-hydroxycholesterol and cholesterol . ECO:0000269|PubMed:17428193, ECO:0000269|PubMed:18270267,; Belongs to the OSBP family.
Synonyms: OSBPL3, OSBPL3p, hOSBPL3, C9J8P4, C9JEF2 ...