DISEASES

Disease-gene associations mined from literature

Literature on TNKS

TNKS [ENSP00000311579]

Poly [ADP-ribose] polymerase tankyrase-1; Poly-ADP-ribosyltransferase involved in various processes such as Wnt signaling pathway, telomere length and vesicle trafficking (PubMed:10988299, PubMed:11739745, PubMed:16076287, PubMed:19759537, PubMed:21478859, PubMed:22864114, PubMed:23622245, PubMed:25043379). Acts as an activator of the Wnt signaling pathway by mediating poly- ADP-ribosylation (PARsylation) of AXIN1 and AXIN2, 2 key components of the beta-catenin destruction complex: poly-ADP-ribosylated target proteins are recognized by RNF146, which mediates their ubiquitination and subsequent degradation . Also mediates PARsylation of BLZF1 and CASC3, followed by recruitment of RNF146 and subsequent ubiquitination . Mediates PARsylation of TERF1, thereby contributing to the regulation of telomere length . Involved in centrosome maturation during prometaphase by mediating PARsylation of HEPACAM2/MIKI . May also regulate vesicle trafficking and modulate the subcellular distribution of SLC2A4/GLUT4-vesicles . May be involved in spindle pole assembly through PARsylation of NUMA1 . Stimulates 26S proteasome activity . ECO:0000269|PubMed:11739745, ECO:0000269|PubMed:16076287, ECO:0000269|PubMed:19759537, ECO:0000269|PubMed:21478859, ECO:0000269|PubMed:22864114, ECO:0000269|PubMed:23622245,

Synonyms:  TNKS,  A0A0C4DGE3,  E5RHD2,  E7EQ52,  E7EWY6 ...

Linkouts:  STRING  Pharos  UniProt  OMIM