DISEASES

Disease-gene associations mined from literature

Literature on VPS26C

VPS26C [ENSP00000311399]

Vacuolar protein sorting-associated protein 26C; Acts as component of the retriever complex. The retriever complex is a heterotrimeric complex related to retromer cargo-selective complex (CSC) and essential for retromer-independent retrieval and recycling of numerous cargos such as integrin alpha-5/beta-1 (ITGA5:ITGB1) . The recruitment of the retriever complex to the endosomal membrane involves CCC and WASH complexes . In the endosomes, drives the retriever and recycling of NxxY-motif-containing cargo proteins by coupling to SNX17, a cargo essential for the homeostatic maintenance of numerous cell surface proteins associated with processes that include cell migration, cell adhesion, nutrient supply and cell signaling . ; Belongs to the VPS26 family.

Synonyms:  VPS26C,  VPS26Cp,  hVPS26C,  A8MTY9,  A8MY26 ...

Linkouts:  STRING  Pharos  UniProt  OMIM