DISEASES

Disease-gene associations mined from literature

Literature on TRMT61B

TRMT61B [ENSP00000302801]

tRNA (adenine(58)-N(1))-methyltransferase, mitochondrial; Methyltransferase that catalyzes the formation of N(1)- methyladenine at position 58 (m1A58) in various tRNAs in mitochondrion, including tRNA(Leu) (deciphering codons UUA or UUG), tRNA(Lys) and tRNA(Ser) (deciphering codons UCA, UCU, UCG or UCC) . Catalyzes the formation of 1-methyladenosine at position 947 of mitochondrial 16S ribosomal RNA and this modification is most likely important for mitoribosomal structure and function . In addition to tRNA N(1)-methyltransferase activity, also acts as a mRNA N(1)-methyltransferase by mediating methylation of adenosine residues at the N(1) position of MT-ND5 mRNA, leading to interfere with mitochondrial translation . ; Belongs to the class I-like SAM-binding methyltransferase superfamily. TRM61 family.

Synonyms:  TRMT61B,  TRMT61Bp,  hTRMT61B,  F8WDR2,  H7C2E8 ...

Linkouts:  STRING  Pharos  UniProt