Literature on BMT2
BMT2 [ENSP00000297145]
S-adenosylmethionine sensor upstream of mTORC1; S-adenosyl-L-methionine-binding protein that acts as an inhibitor of mTORC1 signaling via interaction with the GATOR1 and KICSTOR complexes . Acts as a sensor of S-adenosyl-L- methionine to signal methionine sufficiency to mTORC1: in presence of methionine, binds S-adenosyl-L-methionine, leading to disrupt interaction with the GATOR1 and KICSTOR complexes and promote mTORC1 signaling . Upon methionine starvation, S-adenosyl-L- methionine levels are reduced, thereby promoting the association with GATOR1 and KICSTOR, leading to inhibit mTORC1 signaling . Probably also acts as a S-adenosyl-L-methionine- dependent methyltransferase (Potential); Belongs to the BMT2 family.
Synonyms: BMT2, BMT2p, hBMT2, H0Y6Y0, Q1RMZ1 ...