DISEASES

Disease-gene associations mined from literature

Literature on PDE6D

PDE6D [ENSP00000287600]

Retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit delta; Promotes the release of prenylated target proteins from cellular membranes . Modulates the activity of prenylated or palmitoylated Ras family members by regulating their subcellular location . Required for normal ciliary targeting of farnesylated target proteins, such as INPP5E . Modulates the subcellular location of target proteins by acting as a GTP specific dissociation inhibitor (GDI) (By similarity). Increases the affinity of ARL3 for GTP by several orders of magnitude. Stabilizes ARL3-GTP by decreasing the nucleotide dissociation rate (By similarity). ECO:0000269|PubMed:10518933, ECO:0000269|PubMed:22002721, ECO:0000269|PubMed:23559067, ECO:0000269|PubMed:23698361,; Belongs to the PDE6D/unc-119 family.

Synonyms:  PDE6D,  PDE6Dp,  hPDE6D,  B8ZZK5,  C9IZ52 ...

Linkouts:  STRING  Pharos  UniProt  OMIM