DISEASES

Disease-gene associations mined from literature

Literature on ATAD2

ATAD2 [ENSP00000287394]

ATPase family AAA domain-containing protein 2; May be a transcriptional coactivator of the nuclear receptor ESR1 required to induce the expression of a subset of estradiol target genes, such as CCND1, MYC and E2F1. May play a role in the recruitment or occupancy of CREBBP at some ESR1 target gene promoters. May be required for histone hyperacetylation. Involved in the estrogen-induced cell proliferation and cell cycle progression of breast cancer cells.

Synonyms:  ATAD2,  ATAD2p,  hATAD2,  A0A024R9G7,  A0A0B4J211 ...

Linkouts:  STRING  Pharos  UniProt  OMIM