DISEASES

Disease-gene associations mined from literature

Literature on FBXO4

FBXO4 [ENSP00000281623]

F-box only protein 4; Substrate recognition component of a SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex that mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Promotes ubiquitination of CCND1 and its subsequent proteasomal degradation. Recognizes TERF1 and promotes its ubiquitination together with UBE2D1. ECO:0000269|PubMed:16275645, ECO:0000269|PubMed:18598945,

Synonyms:  FBXO4,  FBXO4p,  hFBXO4,  D6RAJ6,  D6RAU6 ...

Linkouts:  STRING  Pharos  UniProt  OMIM