DISEASES

Disease-gene associations mined from literature

Literature on DBR1

DBR1 [ENSP00000260803]

Lariat debranching enzyme; Cleaves the 2'-5' phosphodiester linkage at the branch point of lariat intron pre-mRNAs after splicing and converts them into linear molecules that are subsequently degraded. It thereby facilitates ribonucleotide turnover. It may also participate in retrovirus replication via an RNA lariat intermediate in cDNA synthesis. ; Belongs to the lariat debranching enzyme family.

Synonyms:  DBR1,  DBR1p,  hDBR1,  F8WAY1,  Q9UK59 ...

Linkouts:  STRING  Pharos  UniProt  OMIM