DISEASES

Disease-gene associations mined from literature

Literature on PABPC1

PABPC1 [ENSP00000313007]

Polyadenylate-binding protein 1; Binds the poly(A) tail of mRNA, including that of its own transcript, and regulates processes of mRNA metabolism such as pre-mRNA splicing and mRNA stability (PubMed:11051545, PubMed:17212783, PubMed:25480299). Its function in translational initiation regulation can either be enhanced by PAIP1 or repressed by PAIP2 (PubMed:11051545, PubMed:20573744). Can probably bind to cytoplasmic RNA sequences other than poly(A) in vivo. Involved in translationally coupled mRNA turnover . Implicated with other RNA-binding proteins in the cytoplasmic deadenylation/translational and decay interplay of the FOS mRNA mediated by the major coding-region determinant of instability (mCRD) domain . Involved in regulation of nonsense- mediated decay (NMD) of mRNAs containing premature stop codons; for the recognition of premature termination codons (PTC) and initiation of NMD a competitive interaction between UPF1 and PABPC1 with the ribosome- bound release factors is proposed . By binding to long poly(A) tails, may protect them from uridylation by ZCCHC6/ZCCHC11 and hence contribute to mRNA stability . ECO:0000269|PubMed:18447585, ECO:0000269|PubMed:20573744,

Synonyms:  PABPC1,  PABPC1p,  hPABPC1,  A0A024R9C1,  A0A087WTT1 ...

Linkouts:  STRING  Pharos  UniProt  OMIM