DISEASES

Disease-gene associations mined from literature

Literature on KLKB1

KLKB1 [ENSP00000264690]

Plasma kallikrein heavy chain; The enzyme cleaves Lys-Arg and Arg-Ser bonds. It activates, in a reciprocal reaction, factor XII after its binding to a negatively charged surface. It also releases bradykinin from HMW kininogen and may also play a role in the renin-angiotensin system by converting prorenin into renin; Belongs to the peptidase S1 family. Plasma kallikrein subfamily.

Synonyms:  KLKB1,  KLKB1p,  hKLKB1,  C9J075,  C9JCT1 ...

Linkouts:  STRING  Pharos  UniProt  OMIM