DISEASES

Disease-gene associations mined from literature

Literature on UBE2V2

UBE2V2 [ENSP00000428209]

Ubiquitin-conjugating enzyme E2 variant 2; Has no ubiquitin ligase activity on its own. The UBE2V2/UBE2N heterodimer catalyzes the synthesis of non-canonical poly-ubiquitin chains that are linked through 'Lys-63'. This type of poly- ubiquitination does not lead to protein degradation by the proteasome. Mediates transcriptional activation of target genes. Plays a role in the control of progress through the cell cycle and differentiation. Plays a role in the error-free DNA repair pathway and contributes to the survival of cells after DNA damage. ECO:0000269|PubMed:14562038, ECO:0000269|PubMed:20061386,

Synonyms:  UBE2V2,  UBE2V2p,  hUBE2V2,  A0M8W4,  E5RIF1 ...

Linkouts:  STRING  Pharos  UniProt  OMIM