DISEASES

Disease-gene associations mined from literature

Literature on USP46

USP46 [ENSP00000407818]

Ubiquitin carboxyl-terminal hydrolase 46; Deubiquitinating enzyme that plays a role in behavior, possibly by regulating GABA action. May act by mediating the deubiquitination of GAD1/GAD67 (By similarity). Has almost no deubiquitinating activity by itself and requires the interaction with WDR48 to have a high activity . Not involved in deubiquitination of monoubiquitinated FANCD2 .

Synonyms:  USP46,  USP46p,  hUSP46,  D6R9Z4,  D6RIX7 ...

Linkouts:  STRING  Pharos  UniProt  OMIM