DISEASES

Disease-gene associations mined from literature

Literature on DNAJC7

DNAJC7 [ENSP00000406463]

DnaJ homolog subfamily C member 7; Acts as co-chaperone regulating the molecular chaperones HSP70 and HSP90 in folding of steroid receptors, such as the glucocorticoid receptor and the progesterone receptor. Proposed to act as a recycling chaperone by facilitating the return of chaperone substrates to early stages of chaperoning if further folding is required. In vitro, induces ATP-independent dissociation of HSP90 but not of HSP70 from the chaperone-substrate complexes. Recruits NR1I3 to the cytoplasm (By similarity).

Synonyms:  DNAJC7,  DNAJC7p,  hDNAJC7,  K7EIH8,  K7EJ24 ...

Linkouts:  STRING  Pharos  UniProt  OMIM