DISEASES

Disease-gene associations mined from literature

Literature on MGAT5B

MGAT5B [ENSP00000391227]

Alpha-1,6-mannosylglycoprotein 6-beta-N-acetylglucosaminyltransferase B; Glycosyltransferase that acts on alpha-linked mannose of N- glycans and O-mannosyl glycans. Catalyzes the transfer of N- acetylglucosamine (GlcNAc) to the beta 1-6 linkage of the mannose residue of GlcNAc-beta1,2-Man-alpha on both the alpha1,3- and alpha1,6- linked mannose arms in the core structure of N-glycan. Also acts on the GlcNAc-beta1,2-Man-alpha1-Ser/Thr moiety, forming a 2,6-branched structure in brain O-mannosyl glycan. Plays an active role in modulating integrin and laminin-dependent adhesion and migration of neuronal cells via its activity in the O-mannosyl glycan pathway. ECO:0000269|PubMed:14623122, ECO:0000269|PubMed:16606368,

Synonyms:  MGAT5B,  MGAT5Bp,  hMGAT5B,  H3BQ65,  H3BR20 ...

Linkouts:  STRING  Pharos  UniProt  OMIM