DISEASES

Disease-gene associations mined from literature

Literature on PLXNA2

PLXNA2 [ENSP00000356000]

Plexin-A2; Coreceptor for SEMA3A and SEMA6A. Necessary for signaling by SEMA6A and class 3 semaphorins and subsequent remodeling of the cytoskeleton. Plays a role in axon guidance, invasive growth and cell migration. Class 3 semaphorins bind to a complex composed of a neuropilin and a plexin. The plexin modulates the affinity of the complex for specific semaphorins, and its cytoplasmic domain is required for the activation of down-stream signaling events in the cytoplasm (By similarity).

Synonyms:  PLXNA2,  PLXNA2p,  hPLXNA2,  O75051,  O75051p ...

Linkouts:  STRING  Pharos  UniProt  OMIM