DISEASES

Disease-gene associations mined from literature

Literature on PCBP2

PCBP2 [ENSP00000352438]

Poly(rC)-binding protein 2; Single-stranded nucleic acid binding protein that binds preferentially to oligo dC. Major cellular poly(rC)-binding protein. Binds also poly(rU). Negatively regulates cellular antiviral responses mediated by MAVS signaling . It acts as an adapter between MAVS and the E3 ubiquitin ligase ITCH, therefore triggering MAVS ubiquitination and degradation .

Synonyms:  PCBP2,  PCBP2p,  hPCBP2,  A0A384N6B9,  F8VRH0 ...

Linkouts:  STRING  Pharos  UniProt  OMIM