DISEASES

Disease-gene associations mined from literature

Literature on LRRC25

LRRC25 [ENSP00000340983]

Leucine-rich repeat-containing protein 25; Plays a role in the inhibition of RLR-mediated type I interferon signaling pathway by targeting DDX58/RIG-I for autophagic degradation. Interacts specifically with ISG15-associated DDX58 to promote interaction between DDX58 and the autophagic cargo receptor p62/SQSTM1 to mediate DDX58 degradation via selective autophagy . Plays also a role in the inhibition of NF-kappa-B signaling pathway and inflammatory response by promoting the degradation of p65/RELA.

Synonyms:  LRRC25,  LRRC25p,  hLRRC25,  Q8N386,  Q8N386p ...

Linkouts:  STRING  Pharos  UniProt  OMIM