DISEASES

Disease-gene associations mined from literature

Literature on ERCC6L

ERCC6L [ENSP00000334675]

DNA excision repair protein ERCC-6-like; DNA helicase that acts as an essential component of the spindle assembly checkpoint. Contributes to the mitotic checkpoint by recruiting MAD2 to kinetochores and monitoring tension on centromeric chromatin . Acts as a tension sensor that associates with catenated DNA which is stretched under tension until it is resolved during anaphase . Functions as ATP-dependent DNA translocase . Can promote Holliday junction branch migration (in vitro) .

Synonyms:  ERCC6L,  ERCC6Lp,  hERCC6L,  B5MDQ0,  Q2NKX8 ...

Linkouts:  STRING  Pharos  UniProt  OMIM