Literature on RFTN1
RFTN1 [ENSP00000334153]
Raftlin; Involved in protein trafficking via association with clathrin and AP2 complex . Upon bacterial lipopolysaccharide stimulation, mediates internalization of TLR4 to endosomes in dendritic cells and macrophages; and internalization of poly(I:C) to TLR3-positive endosomes in myeloid dendritic cells and epithelial cells; resulting in activation of TICAM1-mediated signaling and subsequent IFNB1 production . Involved in T-cell antigen receptor-mediated signaling by regulating tyrosine kinase LCK localization, T-cell dependent antibody production and cytokine secretion (By similarity). May regulate B-cell antigen receptor-mediated signaling . May play a pivotal role in the formation and/or maintenance of lipid rafts . ; Belongs to the raftlin family.
Synonyms: RFTN1, RFTN1p, hRFTN1, C9JHG2, C9JRN3 ...