DISEASES

Disease-gene associations mined from literature

Literature on H2AC21

H2AC21 [ENSP00000332790]

Histone H2A type 2-B; Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.

Synonyms:  H2AC21,  H2AC21p,  hH2AC21,  HIST2H2AB,  Q8IUE6 ...

Linkouts:  STRING  Pharos  UniProt  OMIM