DISEASES

Disease-gene associations mined from literature

Literature on ALG8

ALG8 [ENSP00000299626]

Probable dolichyl pyrophosphate Glc1Man9GlcNAc2 alpha-1,3-glucosyltransferase; Adds the second glucose residue to the lipid-linked oligosaccharide precursor for N-linked glycosylation. Transfers glucose from dolichyl phosphate glucose (Dol-P-Glc) onto the lipid-linked oligosaccharide Glc(1)Man(9)GlcNAc(2)-PP-Dol before it is transferred to the nascent peptide (By similarity). Required for PKD1/Polycystin-1 maturation and localization to the plasma membrane of the primary cilia (By similarity); Belongs to the ALG6/ALG8 glucosyltransferase family.

Synonyms:  ALG8,  ALG8p,  hALG8,  A0A024R5K5,  E9PK79 ...

Linkouts:  STRING  Pharos  UniProt  OMIM