DISEASES

Disease-gene associations mined from literature

Literature on VIRMA

VIRMA [ENSP00000297591]

Protein virilizer homolog; Associated component of the WMM complex, a complex that mediates N6-methyladenosine (m6A) methylation of RNAs, a modification that plays a role in the efficiency of mRNA splicing and RNA processing . Acts as a key regulator of m6A methylation by promoting m6A methylation of mRNAs in the 3'-UTR near the stop codon: recruits the catalytic core components METTL3 and METTL14, thereby guiding m6A methylation at specific sites . Required for mRNA polyadenylation via its role in selective m6A methylation: m6A methylation of mRNAs in the 3'-UTR near the stop codon correlating with alternative polyadenylation (APA) ; Belongs to the vir family.

Synonyms:  VIRMA,  H0YB68,  H0YBN5,  H0YC41,  Q69YN4 ...

Linkouts:  STRING  Pharos  UniProt