DISEASES

Disease-gene associations mined from literature

Literature on PREX2

PREX2 [ENSP00000288368]

Phosphatidylinositol 3,4,5-trisphosphate-dependent Rac exchanger 2 protein; Functions as a RAC1 guanine nucleotide exchange factor (GEF), activating Rac proteins by exchanging bound GDP for free GTP. Its activity is synergistically activated by phosphatidylinositol 3,4,5- trisphosphate and the beta gamma subunits of heterotrimeric G protein. Mediates the activation of RAC1 in a PI3K-dependent manner. May be an important mediator of Rac signaling, acting directly downstream of both G protein-coupled receptors and phosphoinositide 3-kinase.

Synonyms:  PREX2,  PREX2p,  hPREX2,  Q70Z35,  Q70Z35p ...

Linkouts:  STRING  Pharos  UniProt  OMIM