DISEASES

Disease-gene associations mined from literature

Literature on RNF165

RNF165 [ENSP00000269439]

E3 ubiquitin-protein ligase RNF165; E3 ubiquitin-protein ligase that acts as a regulator of motor axon elongation. Required for efficient motor axon extension in the dorsal forelimb by enhancing the transcriptional responses of the SMAD1/SMAD5/SMAD8 effectors, which are activated downstream of BMP. Acts by mediating ubiquitination and degradation of SMAD inhibitors such as SMAD6, SMAD7, SKI and SNON isoform of SKIL. ; Belongs to the Arkadia family.

Synonyms:  RNF165,  RNF165p,  hRNF165,  A0A059NXK6,  ARKL2 ...

Linkouts:  STRING  Pharos  UniProt