Literature on RNF165
RNF165 [ENSP00000269439]
E3 ubiquitin-protein ligase RNF165; E3 ubiquitin-protein ligase that acts as a regulator of motor axon elongation. Required for efficient motor axon extension in the dorsal forelimb by enhancing the transcriptional responses of the SMAD1/SMAD5/SMAD8 effectors, which are activated downstream of BMP. Acts by mediating ubiquitination and degradation of SMAD inhibitors such as SMAD6, SMAD7, SKI and SNON isoform of SKIL. ; Belongs to the Arkadia family.
Synonyms: RNF165, RNF165p, hRNF165, A0A059NXK6, ARKL2 ...