DISEASES

Disease-gene associations mined from literature

Literature on METTL16

METTL16 [ENSP00000263092]

RNA N6-adenosine-methyltransferase METTL16; RNA N6-methyltransferase that methylates adenosine residues at the N(6) position of a subset of RNAs and is involved in S-adenosyl- L-methionine homeostasis by regulating expression of MAT2A transcripts . Able to N6- methylate a subset of mRNAs and U6 small nuclear RNAs (U6 snRNAs) . In contrast to the METTL3-METTL14 heterodimer, only able to methylate a limited number of RNAs: requires both a 5'UACAGAGAA-3' nonamer sequence and a specific RNA structure . Plays a key role in S-adenosyl-L-methionine homeostasis by mediating N6-methylation of MAT2A mRNAs, altering splicing and/or stability of MAT2A transcripts: in presence of S-adenosyl-L-methionine, binds the 3'-UTR region of MAT2A mRNA and specifically N6-methylates the first hairpin of MAT2A mRNA, impairing MAT2A expression . In S-adenosyl-L- methionine-limiting conditions, binds the 3'-UTR region of MAT2A mRNA but stalls due to the lack of a methyl donor, preventing N6-methylation and promoting expression of MAT2A . In addition to mRNAs, also able to mediate N6-methylation of U6 small nuclear RNA (U6 snRNA): specifically N6-methylates adenine in position 43 of U6 snRNAs . Also able to bind various lncRNAs . Specifically binds the 3'-end of the MALAT1 long non-coding RNA . ECO:0000269|PubMed:28525753, ECO:0000269|PubMed:29051200,

Synonyms:  METTL16,  METTL16p,  hMETTL16,  I3L362,  I3L3W3 ...

Linkouts:  STRING  Pharos  UniProt