DISEASES

Disease-gene associations mined from literature

Literature on SMPD3

SMPD3 [ENSP00000219334]

Sphingomyelin phosphodiesterase 3; Catalyzes the hydrolysis of sphingomyelin to form ceramide and phosphocholine. Ceramide mediates numerous cellular functions, such as apoptosis and growth arrest, and is capable of regulating these 2 cellular events independently. Also hydrolyzes sphingosylphosphocholine. Regulates the cell cycle by acting as a growth suppressor in confluent cells. Probably acts as a regulator of postnatal development and participates in bone and dentin mineralization; Belongs to the neutral sphingomyelinase family.

Synonyms:  SMPD3,  SMPD3p,  hSMPD3,  H3BS51,  H3BTM0 ...

Linkouts:  STRING  Pharos  UniProt  OMIM